Retrospective analysis of population 143 pharmacokinetic data following single and multiple dose administration of 4 mg 144 tizanidine, however, showed that women concurrently taking oral contraceptives 145 had 50% lower clearance of tizanidine compared to women not on oral Jul 6, 2023 · 7
It is a centrally acting alpha-2 receptor agonist
However, if concomitant use is clinically necessary, initiate tizanidine hydrochloride with a single 2 mg dose and increase in 2 to 4 mg steps daily based on patient response to therapy
7
1) Dosage can be increased by 2 mg to 4 mg per dose, with 1 to 4 daysbetween increases; total daily dose should not exceed 36 mg (2
It is usually taken consistently either always with or always without food two or three times a day
It is taken by mouth
Liver enzymes (specifically aminotransferase) should be monitored when starting treatment Tizanidine hydrochloride is contraindicated in patients taking potent inhibitors of CYP1A2, such as fluvoxamine or ciprofloxacin [see - Drug Interactions (7
Combined estrogen-progestin oral contraceptives (COCs), also known as birth control pills, provide reliable contraception as well as several noncontraceptive benefits
Tizanidine HCl (tizanidine) is a white to off-white, fine crystalline powder, which is odorless or with a faint characteristic CLINICAL PHARMACOLOGY Combined hormonal contraceptives are moderate inhibitors of CYP1A2
Concomitant use of Zanaflex with oral contraceptives is not recommended
2 DOSAGE AND ADMINISTRATION Yaz birth control pills and Climara, a hormone patch for menopause, will both now be available for a fraction of their list prices, including Cost Plus's standard 15% markup and shipping
However, if concomitant use is clinically necessary, initiate tizanidine with a single 2 mg dose and increase in 2 to 4 mg steps daily based on patient response to therapy
However, if concomitant use is clinically necessary Concomitant use of tizanidine with oral contraceptives is not recommended
However, if concomitant use is clinically necessary, initiate tizanidine with a single 2 mg dose and increase in 2-4 mg steps daily based on patient response to therapy
However, if concomitant use is clinically necessary, initiate tizanidine with a single 2 mg dose and increase in 2-4 mg steps daily based on patient response to therapy
Concomitant use of tizanidine with oral contraceptives is not recommended
However, if concomitant use is clinically necessary, initiate tizanidine with a single 2 mg dose and increase in 2 to 4 mg steps daily based on patient response to therapy
Because drug interaction studies of tizanidine with oral contraceptives have shown that concomitant use may reduce the clearance of tizanidine by as much as 50%, concomitant use of tizanidine with oral contraceptives should ordinarily be avoided (see CLINICAL PHARMACOLOGY: Drug Interactions)
showed that women concurrently taking oral contraceptives had 50% lower clearance of tizanidine compared to Concomitant use of tizanidine with oral contraceptives is not recommended
However, if concomitant use is clinically necessary, initiate tizanidine with a single 2 mg dose and increase in 2-4 mg steps daily based on patient response to therapy
If adverse reactions such as hypotension, bradycardia, or excessive drowsiness occur, reduce or 7
4 Oral Contraceptives
If adverse reactions such as hypotension, bradycardia, or excessive drowsiness occur, reduce or Use in Women Taking Oral Contraceptives
However, if concomitant use is clinically necessary, initiate tizanidine with a single 2 mg dose and increase in 2-4 mg steps daily based on patient response to therapy
However, if concomitant use is clinically necessary, initiate tizanidine with a single 2 mg dose and increase in 2 to 4 mg steps daily based on patient response to therapy
Concomitant use of tizanidine with oral contraceptives is not recommended
However, if concomitant use is clinically necessary, initiate tizanidine hydrochloride with a single 2 mg dose and increase in 2 to 4 mg steps daily based on patient response to therapy
Because drug interaction studies of tizanidine with oral contraceptives have shown that concomitant use may reduce the clearance of tizanidine by as much as 50%, concomitant use of tizanidine with oral contraceptives should ordinarily be avoided (see CLINICAL PHARMACOLOGY: Drug Interactions)
Sedation: tizanidine hydrochloride may interfere with everyday activities; sedative effects of tizanidine hydrochloride, alcohol, and other CNS depressants are additive other fluoroquinolones, antiarrythmics , cimetidine, famotidine, oral contraceptives, acyclovir, and ticlopidine (5
Concomitant use of tizanidine hydrochloride with oral contraceptives is not recommended
Concomitant use of tizanidine hydrochloride with oral contraceptives is not recommended
If adverse reactions such as hypotension, bradycardia, or excessive drowsiness occur, reduce or discontinue tizanidine therapy
4 Oral Contraceptives
Tizanidine oral tablet is available as both a generic and brand-name drug
Use Caution/Monitor
DESCRIPTION Zanaflex® (tizanidine hydrochloride) is a centrally acting α2-adrenergic agonist
However, if concomitant use is clinically necessary, initiate tizanidine hydrochloride
Concomitant use of tizanidine hydrochloride with oral contraceptives is not recommended
Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450
Retrospective analysis of population pharmacokinetic data following single and multiple dose administration of 4 mg tizanidine, however, showed that women concurrently taking oral
Tizanidine is contraindicated in patients taking potent inhibitors of CYP1A2, such as fluvoxamine or ciprofloxacin [see Drug Interactions (7
Because drug interaction studies of tizanidine with oral contraceptives have shown that concomitant use may reduce the clearance of tizanidine by as much as 50%, concomitant use of tizanidine with oral contraceptives should ordinarily be avoided (see CLINICAL PHARMACOLOGY: Drug
11 adverse reactions such as hypotension, bradycardia, or excessive drowsiness occur
Concomitant use of tizanidine with oral contraceptives is not recommended
4 Oral Contraceptives
However, if concomitant use is clinically necessary, initiate tizanidine with a single 2 mg dose and increase in 2–4 mg steps daily based on patient response to therapy
However, if concomitant use is clinically necessary, initiate tizanidine hydrochloride with a single 2 mg dose and increase in 2 to 4 mg steps daily based on patient response to therapy
If adverse reactions such as hypotension, bradycardia, or excessive drowsiness occur, reduce or No specific pharmacokinetic study was conducted to investigate interaction between oral contraceptives and tizanidine, but retrospective analysis of population pharmacokinetic data following single and multiple dose administration of 4 mg tizanidine showed that women concurrently taking oral contraceptives had 50% lower clearance of tizanidine Concomitant use of tizanidine with oral contraceptives is not recommended
Following single and multiple oral dosing of 14 C-tizanidine, an average of 60% and 20% of total 7
However, if concomitant use is clinically necessary, initiate tizanidine with a single 2 mg dose and increase in 2 to 4 mg steps daily based on patient response to therapy
However, if concomitant use is clinically necessary, initiate tizanidine with a single 2 mg dose and increase in 2–4 mg steps daily based on patient response to therapy
Tizanidine oral tablet can interact with other medications, vitamins, or herbs you may be taking
Side Effects
Concomitant use of tizanidine hydrochloride with oral contraceptives is not recommended
However, if concomitant use is clinically necessary, initiate Tizanidine Tablets, USP with a single 2 mg dose and increase in 2–4 mg steps daily based on patient response to therapy